WikiPortallus: Diethyltryptamine.html

DET, also known under its chemical name N,N-diethyltryptamine and as T-9 ¹, is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100 mg without the aid of MAO inhibitors lasting about 2-4 hours.

Biochemistry

Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.³

Psychosis model

Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties.⁴ Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis.⁵ With the progression of science and pharmacological understanding this belief remains dismissed by most researchers.

^ "Erowid DET Vault : Chemistry". http://www.erowid.org/chemicals/det/det_chemistry.shtml. Retrieved on 2008-01-08.
^ Winter JC (September 1969). "Behavioral effects of N,N-diethyltryptamine: absence of antagonism by xylamidine tosylate". J. Pharmacol. Exp. Ther. 169 (1): 7–16. PMID 5306645. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=5306645.
^ Gartz J (1989). "Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe". J. Basic Microbiol. 29 (6): 347–52. PMID 2614674.
^ http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2633 "PSILOCYBIN AND DIETHYLTRYPTAMINE: TWO TRYPTAMINE HALLUCINOGENS"]. http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2633. Retrieved on 2008-01-03.
^ "Effects of LSD-25, N,N-Dimethyltryptamine (DMT), and N,N-Diethyltryptamine (DET) on the Photic Evoked Responses in the unanesthetized Rabbit". http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2360. Retrieved on 2008-01-03.

Psychedelic tryptamines

α,N,N-TMT • 2,N,N-TMT • 5,N,N-TMT • 4-Acetoxy-DMT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-HO-5-MeO-DMT • 4-Hydroxy-N-methyl-(α,N-trimethylene)tryptamine • 5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine • α-ET • α-MT • Baeocystin • Bufotenin • DBT • DET • DIPT • DMT • DPT • EiPT • PiPT • Ethocin • Ethocybin • Iprocin • 4-HO-MET • 4-HO-MiPT • MET • MIPT • 5-Me-MIPT • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-EiPT • 5-MeO-MET • 5-MeO-MIPT • 5-MeO-α,N,N-TMT • 5-MeO-2,N,N-TMT • Miprocin • Norbaeocystin • Psilocin • Psilocybin

Drugs from TiHKAL

AL-LAD • DBT • DET • DiPT • 5-MeO-α-MT • DMT • 2,α-DMT • α,N-DMT • DPT • EiPT • α-ET • ETH-LAD • Harmaline • Harmine • 4-HO-DBT • 4-HO-DET • 4-HO-DiPT • 4-HO-DMT • 5-HO-DMT • 4-HO-DPT • 4-HO-MET • 4-HO-MiPT • 4-HO-MPT • 4-HO-pyr-T • Ibogaine • LSD • MBT • 4,5-MDO-DiPT • 5,6-MDO-DiPT • 4,5-MDO-DMT • 5,6-MDO-DMT • 5,6-MDO-MiPT • 2-Me-DET • 2-Me-DMT • Melatonin • 5-MeO-DET • 5-MeO-DiPT • 5-MeO-DMT • 4-MeO-MiPT • 5-MeO-MiPT • 5,6-MeO-MiPT • 5-MeO-NMT • 5-MeO-pyr-T • 6-MeO-THH • 5-MeO-TMT • 5-MeS-DMT • MiPT • α-MT • NET • NMT • PRO-LAD • pyr-T • Tryptamine • Tetrahydroharmine • α,N,O-TMS

Tryptamines

4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-HO-α-MT • 4-HO-DIPT • 5-Bromo-DMT • 5-Carboxamidotryptamine • 5-Fluoro-α-MT • 5-HO-α-MT • 5-Methoxytryptamine • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MIPT • 5,7-Dihydroxytryptamine • α-ET • α-MT • Aeruginascin • BW-723C86 • Baeocystin • Bufotenidine • Bufotenin • DET • DiPT • DMT • DPT • Ethocybin • EiPT • EMDT • Ethocin • Ibogaine • Iprocin • MET • MiPT • Miprocin • Melatonin • MS-245 • NMT • Norbaeocystin • Normelatonin • PiPT • Psilocin • Psilocybin • Rizatriptan • Serotonin • Sumatriptan • Tryptamine • Tryptophan

Diethyltryptamine.html

Contents

Pharmacology

Biochemistry

Psychosis model

See also

References

External links